Reprogramming Eukaryotic Translation with Ligand-Responsive Synthetic RNA Switches

Protein synthesis in eukaryotes is regulated by diverse reprogramming mechanisms that expand the coding capacity of individual genes. Here, we exploit one such mechanism termed −1 programmed ribosomal frameshifting (−1 PRF) to engineer ligand-responsive RNA switches that regulate protein expression....

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Detalles Bibliográficos
Autores principales: Anzalone, Andrew V., Lin, Annie J., Zairis, Sakellarios, Rabadan, Raul, Cornish, Virginia W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850110/
https://www.ncbi.nlm.nih.gov/pubmed/26999002
http://dx.doi.org/10.1038/nmeth.3807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850110/
https://www.ncbi.nlm.nih.gov/pubmed/26999002
http://dx.doi.org/10.1038/nmeth.3807

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