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Reprogramming Eukaryotic Translation with Ligand-Responsive Synthetic RNA Switches
Protein synthesis in eukaryotes is regulated by diverse reprogramming mechanisms that expand the coding capacity of individual genes. Here, we exploit one such mechanism termed −1 programmed ribosomal frameshifting (−1 PRF) to engineer ligand-responsive RNA switches that regulate protein expression....
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850110/ https://www.ncbi.nlm.nih.gov/pubmed/26999002 http://dx.doi.org/10.1038/nmeth.3807 |