Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets

Ubiquitin chains are important post-translational modifications that control a large number of cellular processes. Chains can be formed via different linkages, which determines the type of signal they convey. Deubiquitylating enzymes (DUBs) regulate ubiquitylation status by trimming or removing chai...

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Detalles Bibliográficos
Autores principales: Flierman, Dennis, van der Heden van Noort, Gerbrand J., Ekkebus, Reggy, Geurink, Paul P., Mevissen, Tycho E.T., Hospenthal, Manuela K., Komander, David, Ovaa, Huib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850247/
https://www.ncbi.nlm.nih.gov/pubmed/27066941
http://dx.doi.org/10.1016/j.chembiol.2016.03.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850247/
https://www.ncbi.nlm.nih.gov/pubmed/27066941
http://dx.doi.org/10.1016/j.chembiol.2016.03.009

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