Sequence diversity of NanA manifests in distinct enzyme kinetics and inhibitor susceptibility

Streptococcus pneumoniae is the leading pathogen causing bacterial pneumonia and meningitis. Its surface-associated virulence factor neuraminidase A (NanA) promotes the bacterial colonization by removing the terminal sialyl residues from glycoconjugates on eukaryotic cell surface. The predominant ro...

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Detalles Bibliográficos
Autores principales: Xu, Zhongli, von Grafenstein, Susanne, Walther, Elisabeth, Fuchs, Julian E., Liedl, Klaus R., Sauerbrei, Andreas, Schmidtke, Michaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850393/
https://www.ncbi.nlm.nih.gov/pubmed/27125351
http://dx.doi.org/10.1038/srep25169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850393/
https://www.ncbi.nlm.nih.gov/pubmed/27125351
http://dx.doi.org/10.1038/srep25169

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