Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H

Neutrophils play an important role in the occurrence and development of acute lung injury (ALI). Leukotriene B4 (LTB4), a hydrolysis product of epoxide leukotriene A4 (LTA4) catalyzed by LTA4 hydrolase (LTA4H), is one of the most potent chemoattractants for neutrophil. Bufexamac is a drug widely use...

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Detalles Bibliográficos
Autores principales: Xiao, Qiang, Dong, Ningning, Yao, Xue, Wu, Dang, Lu, Yanli, Mao, Fei, Zhu, Jin, Li, Jian, Huang, Jin, Chen, Aifang, Huang, Lu, Wang, Xuehai, Yang, Guangxiao, He, Guangyuan, Xu, Yong, Lu, Weiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850449/
https://www.ncbi.nlm.nih.gov/pubmed/27126280
http://dx.doi.org/10.1038/srep25298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850449/
https://www.ncbi.nlm.nih.gov/pubmed/27126280
http://dx.doi.org/10.1038/srep25298

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