Trajectories of the healthy ageing phenotype among middle-aged and older Britons, 2004–2013

OBJECTIVES: Since the ageing population demands a response to ensure older people remain healthy and active, we studied the dynamics of a recently proposed healthy ageing phenotype. We drew the phenotype’s trajectories and tested whether their levels and rates of change are influenced by health beha...

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Autor principal: Tampubolon, Gindo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier/North Holland Biomedical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850932/
https://www.ncbi.nlm.nih.gov/pubmed/27105690
http://dx.doi.org/10.1016/j.maturitas.2016.03.002
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author Tampubolon, Gindo
author_facet Tampubolon, Gindo
author_sort Tampubolon, Gindo
collection PubMed
description OBJECTIVES: Since the ageing population demands a response to ensure older people remain healthy and active, we studied the dynamics of a recently proposed healthy ageing phenotype. We drew the phenotype’s trajectories and tested whether their levels and rates of change are influenced by health behaviours, comorbidities and socioeconomic positions earlier in the life course. DESIGN AND OUTCOMES: The English Longitudinal Ageing Study, a prospective, nationally representative sample of people aged ≥50 years, measured a set of eight biomarkers which make up the outcome of the healthy ageing phenotype three times over nearly a decade (N(2004) = 5009, N(2008) = 5301, N(2013) = 4455). A cluster of health behaviours, comorbidities and socioeconomic positions were also measured repeatedly. We assessed the phenotype’s distribution non-parametrically, then fitted linear mixed models to phenotypic change and further examined time interactions with gender and socioeconomic position. We ran additional analyses to test robustness. RESULTS: Women had a wider distribution of the healthy ageing phenotype than men had. The phenotype declined annually by −0.242 (95% confidence interval [CI]: −0.352, −0.131). However, there was considerable heterogeneity in the levels and rates of phenotypic change. Women started at higher levels, then declined more steeply by −0.293 (CI: −0.403, −0.183) annually, leading to crossover in the trajectories. Smoking and physical activity assessed on the Allied Dunbar scale were strongly associated with the trajectories. CONCLUSION: Though marked by secular decline, the trajectories of the healthy ageing phenotype showed distinct socioeconomic gradients. The trajectories were also susceptible to variations in health behaviours, strengthening the case for serial interventions to attain healthy and active ageing.
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spelling pubmed-48509322016-06-01 Trajectories of the healthy ageing phenotype among middle-aged and older Britons, 2004–2013 Tampubolon, Gindo Maturitas Article OBJECTIVES: Since the ageing population demands a response to ensure older people remain healthy and active, we studied the dynamics of a recently proposed healthy ageing phenotype. We drew the phenotype’s trajectories and tested whether their levels and rates of change are influenced by health behaviours, comorbidities and socioeconomic positions earlier in the life course. DESIGN AND OUTCOMES: The English Longitudinal Ageing Study, a prospective, nationally representative sample of people aged ≥50 years, measured a set of eight biomarkers which make up the outcome of the healthy ageing phenotype three times over nearly a decade (N(2004) = 5009, N(2008) = 5301, N(2013) = 4455). A cluster of health behaviours, comorbidities and socioeconomic positions were also measured repeatedly. We assessed the phenotype’s distribution non-parametrically, then fitted linear mixed models to phenotypic change and further examined time interactions with gender and socioeconomic position. We ran additional analyses to test robustness. RESULTS: Women had a wider distribution of the healthy ageing phenotype than men had. The phenotype declined annually by −0.242 (95% confidence interval [CI]: −0.352, −0.131). However, there was considerable heterogeneity in the levels and rates of phenotypic change. Women started at higher levels, then declined more steeply by −0.293 (CI: −0.403, −0.183) annually, leading to crossover in the trajectories. Smoking and physical activity assessed on the Allied Dunbar scale were strongly associated with the trajectories. CONCLUSION: Though marked by secular decline, the trajectories of the healthy ageing phenotype showed distinct socioeconomic gradients. The trajectories were also susceptible to variations in health behaviours, strengthening the case for serial interventions to attain healthy and active ageing. Elsevier/North Holland Biomedical Press 2016-06 /pmc/articles/PMC4850932/ /pubmed/27105690 http://dx.doi.org/10.1016/j.maturitas.2016.03.002 Text en © 2016 The Author http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tampubolon, Gindo
Trajectories of the healthy ageing phenotype among middle-aged and older Britons, 2004–2013
title Trajectories of the healthy ageing phenotype among middle-aged and older Britons, 2004–2013
title_full Trajectories of the healthy ageing phenotype among middle-aged and older Britons, 2004–2013
title_fullStr Trajectories of the healthy ageing phenotype among middle-aged and older Britons, 2004–2013
title_full_unstemmed Trajectories of the healthy ageing phenotype among middle-aged and older Britons, 2004–2013
title_short Trajectories of the healthy ageing phenotype among middle-aged and older Britons, 2004–2013
title_sort trajectories of the healthy ageing phenotype among middle-aged and older britons, 2004–2013
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850932/
https://www.ncbi.nlm.nih.gov/pubmed/27105690
http://dx.doi.org/10.1016/j.maturitas.2016.03.002
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