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Lipopolysaccharide Disrupts Mitochondrial Physiology in Skeletal Muscle via Disparate Effects on Sphingolipid Metabolism

Lipopolysaccharides (LPS) are prevalent pathogenic molecules that are found within tissues and blood. Elevated circulating LPS is a feature of obesity and sepsis, both of which are associated with mitochondrial abnormalities that are key pathological features of LPS excess. However, the mechanism of...

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Detalles Bibliográficos
Autores principales: Hansen, Melissa E., Simmons, Kurtis J., Tippetts, Trevor S., Thatcher, Mikayla O., Saito, Rex R., Hubbard, Sheryl T., Trumbull, Annie M., Parker, Brian A., Taylor, Oliver J., Bikman, Benjamin T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851226/
https://www.ncbi.nlm.nih.gov/pubmed/26529656
http://dx.doi.org/10.1097/SHK.0000000000000468