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AID up-mutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity

DNA deaminases underpin pathways in antibody diversification (AID) and anti-viral immunity (APOBEC3s). Here we show how a high-throughput bacterial papillation assay can be used to screen for AID mutants with increased catalytic activity. The upmutations focus on a small number of residues, some hig...

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Detalles Bibliográficos
Autores principales:	Wang, Meng, Yang, Zizhen, Rada, Cristina, Neuberger, Michael S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851237/ https://www.ncbi.nlm.nih.gov/pubmed/19543289 http://dx.doi.org/10.1038/nsmb.1623

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