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Manipulating the Prion Protein Gene Sequence and Expression Levels with CRISPR/Cas9
The mammalian prion protein (PrP, encoded by Prnp) is most infamous for its central role in prion diseases, invariably fatal neurodegenerative diseases affecting humans, food animals, and animals in the wild. However, PrP is also hypothesized to be an important receptor for toxic protein conformers...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851410/ https://www.ncbi.nlm.nih.gov/pubmed/27128441 http://dx.doi.org/10.1371/journal.pone.0154604 |