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Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR

Chordomas are rare primary malignant bone tumors arising from embryonal notochord remnants of the axial skeleton. Chordomas commonly recur following surgery and radiotherapy, and there is no effective systemic therapy. Previous studies implicated receptor tyrosine kinases, including epidermal growth...

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Detalles Bibliográficos
Autores principales: Aleksic, Tamara, Browning, Lisa, Woodward, Martha, Phillips, Rachel, Page, Suzanne, Henderson, Shirley, Athanasou, Nicholas, Ansorge, Olaf, Whitwell, Duncan, Pratap, Sarah, Hassan, A. Bassim, Middleton, Mark R., Macaulay, Valentine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852191/
https://www.ncbi.nlm.nih.gov/pubmed/27200287
http://dx.doi.org/10.3389/fonc.2016.00098