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Constitutive translation of human α-synuclein is mediated by the 5′-untranslated region

Genetic and biochemical studies have established a central role for α-synuclein (SNCA) accumulation in the pathogenesis of Parkinson's disease. Uncovering and subsequently interfering with physiological mechanisms that control SNCA expression is one approach to limit disease progression. To thi...

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Detalles Bibliográficos
Autores principales: Koukouraki, Pelagia, Doxakis, Epaminondas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852460/
https://www.ncbi.nlm.nih.gov/pubmed/27248657
http://dx.doi.org/10.1098/rsob.160022