Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract
Centella asiatica extract is a rich source of natural bioactive substances, triterpenoid saponins, flavonoids, phenolic acids, triterpenic steroids, amino acids and sugars. Thus, many scavenging free radicals, exhibit antiinflammatory activity and affect on the stratum corneum hydration and epiderma...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852572/ https://www.ncbi.nlm.nih.gov/pubmed/27168678 |
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author | Ratz-Łyko, A. Arct, J. Pytkowska, K. |
author_facet | Ratz-Łyko, A. Arct, J. Pytkowska, K. |
author_sort | Ratz-Łyko, A. |
collection | PubMed |
description | Centella asiatica extract is a rich source of natural bioactive substances, triterpenoid saponins, flavonoids, phenolic acids, triterpenic steroids, amino acids and sugars. Thus, many scavenging free radicals, exhibit antiinflammatory activity and affect on the stratum corneum hydration and epidermal barrier function. The aim of the present study was to evaluate the in vivo moisturizing and antiinflammatory properties of cosmetic formulations (oil-in-water emulsion cream and hydrogel) containing different concentrations of Centella asiatica extract. The study was conducted over four weeks on a group of 25 volunteers after twice a day application of cosmetic formulations with Centella asiatica extract (2.5 and 5%, w/w) on their forearms. The measurement of basic skin parameters (stratum corneum hydration and epidermal barrier function) was performed once a week. The in vivo antiinflammatory activity based on the methyl nicotinate model of microinflammation in human skin was evaluated after four weeks application of tested formulations. In vivo tests formulations containing 5% of Centella asiatica extract showed the best efficacy in improving skin moisture by increase of skin surface hydration state and decrease in transepidermal water loss as well as exhibited antiinflammatory properties based on the methyl nicotinate model of microinflammation in human skin. Comparative tests conducted by corneometer, tewameter and chromameter showed that cosmetic formulations containing Centella asiatica extract have the moisturizing and antiinflammatory properties. |
format | Online Article Text |
id | pubmed-4852572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-48525722016-05-10 Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract Ratz-Łyko, A. Arct, J. Pytkowska, K. Indian J Pharm Sci Research Paper Centella asiatica extract is a rich source of natural bioactive substances, triterpenoid saponins, flavonoids, phenolic acids, triterpenic steroids, amino acids and sugars. Thus, many scavenging free radicals, exhibit antiinflammatory activity and affect on the stratum corneum hydration and epidermal barrier function. The aim of the present study was to evaluate the in vivo moisturizing and antiinflammatory properties of cosmetic formulations (oil-in-water emulsion cream and hydrogel) containing different concentrations of Centella asiatica extract. The study was conducted over four weeks on a group of 25 volunteers after twice a day application of cosmetic formulations with Centella asiatica extract (2.5 and 5%, w/w) on their forearms. The measurement of basic skin parameters (stratum corneum hydration and epidermal barrier function) was performed once a week. The in vivo antiinflammatory activity based on the methyl nicotinate model of microinflammation in human skin was evaluated after four weeks application of tested formulations. In vivo tests formulations containing 5% of Centella asiatica extract showed the best efficacy in improving skin moisture by increase of skin surface hydration state and decrease in transepidermal water loss as well as exhibited antiinflammatory properties based on the methyl nicotinate model of microinflammation in human skin. Comparative tests conducted by corneometer, tewameter and chromameter showed that cosmetic formulations containing Centella asiatica extract have the moisturizing and antiinflammatory properties. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4852572/ /pubmed/27168678 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Research Paper Ratz-Łyko, A. Arct, J. Pytkowska, K. Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract |
title | Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract |
title_full | Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract |
title_fullStr | Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract |
title_full_unstemmed | Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract |
title_short | Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract |
title_sort | moisturizing and antiinflammatory properties of cosmetic formulations containing centella asiatica extract |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852572/ https://www.ncbi.nlm.nih.gov/pubmed/27168678 |
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