PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells

Entry into mitosis is driven by the phosphorylation of thousands of substrates, under the master control of Cdk1. During entry into mitosis, Cdk1, in collaboration with MASTL kinase, represses the activity of the major mitotic protein phosphatases, PP1 and PP2A, thereby ensuring mitotic substrates r...

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Detalles Bibliográficos
Autores principales: Rogers, Samuel, Fey, Dirk, McCloy, Rachael A., Parker, Benjamin L., Mitchell, Nicholas J., Payne, Richard J., Daly, Roger J., James, David E., Caldon, C. Elizabeth, Watkins, D. Neil, Croucher, David R., Burgess, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852720/
https://www.ncbi.nlm.nih.gov/pubmed/26872783
http://dx.doi.org/10.1242/jcs.179754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852720/
https://www.ncbi.nlm.nih.gov/pubmed/26872783
http://dx.doi.org/10.1242/jcs.179754

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