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PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells
Entry into mitosis is driven by the phosphorylation of thousands of substrates, under the master control of Cdk1. During entry into mitosis, Cdk1, in collaboration with MASTL kinase, represses the activity of the major mitotic protein phosphatases, PP1 and PP2A, thereby ensuring mitotic substrates r...
Autores principales: | Rogers, Samuel, Fey, Dirk, McCloy, Rachael A., Parker, Benjamin L., Mitchell, Nicholas J., Payne, Richard J., Daly, Roger J., James, David E., Caldon, C. Elizabeth, Watkins, D. Neil, Croucher, David R., Burgess, Andrew |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852720/ https://www.ncbi.nlm.nih.gov/pubmed/26872783 http://dx.doi.org/10.1242/jcs.179754 |
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