Papaverine Prevents Vasospasm by Regulation of Myosin Light Chain Phosphorylation and Actin Polymerization in Human Saphenous Vein

OBJECTIVE: Papaverine is used to prevent vasospasm in human saphenous veins (HSV) during vein graft preparation prior to implantation as a bypass conduit. Papaverine is a nonspecific inhibitor of phosphodiesterases, leading to increases in both intracellular cGMP and cAMP. We hypothesized that papav...

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Detalles Bibliográficos
Autores principales: Hocking, Kyle M., Putumbaka, Gowthami, Wise, Eric S., Cheung-Flynn, Joyce, Brophy, Colleen M., Komalavilas, Padmini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852981/
https://www.ncbi.nlm.nih.gov/pubmed/27136356
http://dx.doi.org/10.1371/journal.pone.0154460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852981/
https://www.ncbi.nlm.nih.gov/pubmed/27136356
http://dx.doi.org/10.1371/journal.pone.0154460

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