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mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation
Breast cancer is the leading cause of cancer-related deaths among women. Approximately 75% of breast cancers are estrogen receptor α (ERα) positive, underscoring the dependence of cancer cells on estrogen for growth and survival. Patients treated with endocrine therapy often develop resistance, eith...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853282/ https://www.ncbi.nlm.nih.gov/pubmed/26522726 http://dx.doi.org/10.1038/onc.2015.414 |