DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells

Promoter DNA methylation is a key epigenetic mechanism for stable gene silencing, but is correlated with expression when located in gene bodies. Maintenance and de novo DNA methylation by catalytically active DNA methyltransferases (DNMT1 and DNMT3A/B) require accessory proteins such as UHRF1 and DN...

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Detalles Bibliográficos
Autores principales: Duymich, Christopher E., Charlet, Jessica, Yang, Xiaojing, Jones, Peter A., Liang, Gangning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853477/
https://www.ncbi.nlm.nih.gov/pubmed/27121154
http://dx.doi.org/10.1038/ncomms11453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853477/
https://www.ncbi.nlm.nih.gov/pubmed/27121154
http://dx.doi.org/10.1038/ncomms11453

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