Enhanced Anti-tumor Reactivity of Cytotoxic T Lymphocytes Expressing PD-1 Decoy

Programmed death-1 (PD-1) is a strong negative regulator of T lymphocytes in tumor-microenvironment. By engaging PD-1 ligand (PD-L1) on tumor cells, PD-1 on T cell surface inhibits anti-tumor reactivity of tumor-infiltrating T cells. Systemic blockade of PD-1 function using blocking antibodies has s...

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Detalles Bibliográficos
Autores principales: Shin, Jae Hun, Park, Hyung Bae, Choi, Kyungho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2016
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853499/
https://www.ncbi.nlm.nih.gov/pubmed/27162530
http://dx.doi.org/10.4110/in.2016.16.2.134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853499/
https://www.ncbi.nlm.nih.gov/pubmed/27162530
http://dx.doi.org/10.4110/in.2016.16.2.134

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