A novel assay for screening inhibitors targeting HIV-1 integrase dimerization based on Ni-NTA magnetic agarose beads

Human immunodeficiency virus (HIV)-1 integrase (IN), which mediates integration of viral cDNA into the cellular chromosome, is a validated antiviral drug target. Three IN inhibitors, raltegravir, elvitegravir and dolutegravir, have been clinically approved since 2008. However, drug resistance have e...

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Detalles Bibliográficos
Autores principales: Zhang, Dawei, He, Hongqiu, Liu, Mengmeng, Meng, Zhixia, Guo, Shunxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853713/
https://www.ncbi.nlm.nih.gov/pubmed/27137477
http://dx.doi.org/10.1038/srep25375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853713/
https://www.ncbi.nlm.nih.gov/pubmed/27137477
http://dx.doi.org/10.1038/srep25375

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