Design, Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified Combretastatin A-4 (CA-4) Analogues as Potent Antitubulin Agents

A series of 12 novel acylhydrazone, chalcone and amide–bridged analogues of combretastatin A-4 were designed and synthesized toward tubulin. All these compounds were determined by elemental analysis, (1)H NMR, and MS. Among them, compound 7 with acylhydrazone-bridge, bearing a benzyl at the indole-N...

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Detalles Bibliográficos
Autores principales: Duan, Yong-Tao, Man, Ruo-Jun, Tang, Dan-Jie, Yao, Yong-Fang, Tao, Xiang-Xiang, Yu, Chen, Liang, Xin-Yi, Makawana, Jigar A., Zou, Mei-Juan, Wang, Zhong-Chang, Zhu, Hai-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853715/
https://www.ncbi.nlm.nih.gov/pubmed/27138035
http://dx.doi.org/10.1038/srep25387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853715/
https://www.ncbi.nlm.nih.gov/pubmed/27138035
http://dx.doi.org/10.1038/srep25387

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