Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

The p53 pro-apoptotic tumor suppressor is mutated or functionally altered in most cancers. In epithelial tumors induced by “high-risk” mucosal Human Papillomaviruses (hrm-HPVs), including human cervical carcinoma and a growing number of head-and-neck cancers (1), p53 is degraded by the viral oncopro...

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Detalles Bibliográficos
Autores principales: Martinez-Zapien, Denise, Ruiz, Francesc Xavier, Poirson, Juline, Mitschler, André, Ramirez-Ramos, Juan, Forster, Anne, Cousido-Siah, Alexandra, Masson, Murielle, Pol, Scott Vande, Podjarny, Alberto, Travé, Gilles, Zanier, Katia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853763/
https://www.ncbi.nlm.nih.gov/pubmed/26789255
http://dx.doi.org/10.1038/nature16481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853763/
https://www.ncbi.nlm.nih.gov/pubmed/26789255
http://dx.doi.org/10.1038/nature16481

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