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Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

The p53 pro-apoptotic tumor suppressor is mutated or functionally altered in most cancers. In epithelial tumors induced by “high-risk” mucosal Human Papillomaviruses (hrm-HPVs), including human cervical carcinoma and a growing number of head-and-neck cancers (1), p53 is degraded by the viral oncopro...

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Detalles Bibliográficos
Autores principales:	Martinez-Zapien, Denise, Ruiz, Francesc Xavier, Poirson, Juline, Mitschler, André, Ramirez-Ramos, Juan, Forster, Anne, Cousido-Siah, Alexandra, Masson, Murielle, Pol, Scott Vande, Podjarny, Alberto, Travé, Gilles, Zanier, Katia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853763/ https://www.ncbi.nlm.nih.gov/pubmed/26789255 http://dx.doi.org/10.1038/nature16481

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