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Combined sodium ion sensitivity in agonist binding and internalization of vasopressin V1b receptors

Reducing Na(+) in the extracellular environment may lead to two beneficial effects for increasing agonist binding to cell surface G-protein coupled receptors (GPCRs): reduction of Na(+)-mediated binding block and reduce of receptor internalization. However, such combined effects have not been explor...

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Detalles Bibliográficos
Autores principales: Koshimizu, Taka-aki, Kashiwazaki, Aki, Taniguchi, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853784/
https://www.ncbi.nlm.nih.gov/pubmed/27138239
http://dx.doi.org/10.1038/srep25327