Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

Lenalidomide is a highly effective treatment for myelodysplastic syndrome (MDS) with deletion of chromosome 5q (del(5q)). Here, we demonstrate that lenalidomide induces the ubiquitination of casein kinase 1A1 (CK1α) by the CRL4(CRBN) E3 ubiquitin ligase, resulting in CK1α degradation. CK1α is encode...

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Detalles Bibliográficos
Autores principales: Krönke, Jan, Fink, Emma C., Hollenbach, Paul W., MacBeth, Kyle J., Hurst, Slater N., Udeshi, Namrata D., Chamberlain, Philip P., Mani, D.R., Man, Hon Wah, Gandhi, Anita K., Svinkina, Tanya, Schneider, Rebekka K., McConkey, Marie, Järås, Marcus, Griffiths, Elizabeth, Wetzler, Meir, Bullinger, Lars, Cathers, Brian E., Carr, Steven A., Chopra, Rajesh, Ebert, Benjamin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853910/
https://www.ncbi.nlm.nih.gov/pubmed/26131937
http://dx.doi.org/10.1038/nature14610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853910/
https://www.ncbi.nlm.nih.gov/pubmed/26131937
http://dx.doi.org/10.1038/nature14610

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