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Effect of folate status and methylenetetrahydrofolate reductase genotypes on the complications and outcome of high dose methotrexate chemotherapy in north Indian children with acute lymphoblastic leukemia

PURPOSE: The genes of the folate metabolic pathway have been associated with toxicities during high dose methotrexate therapy for childhood ALL, however, the importance of intrinsic folate status in this regard is unclear. METHODS: In the present study the effect of precourse folate levels and MTHFR...

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Detalles Bibliográficos
Autores principales: Moulik, Nirmalya Roy, Kumar, Archana, Agrawal, Suraksha, Mahdi, Abbas Ali, Kumar, Ashutosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854052/
https://www.ncbi.nlm.nih.gov/pubmed/27168705
http://dx.doi.org/10.4103/0971-5851.180144