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Functional Sites Induce Long-Range Evolutionary Constraints in Enzymes

Functional residues in proteins tend to be highly conserved over evolutionary time. However, to what extent functional sites impose evolutionary constraints on nearby or even more distant residues is not known. Here, we report pervasive conservation gradients toward catalytic residues in a dataset o...

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Detalles Bibliográficos
Autores principales: Jack, Benjamin R., Meyer, Austin G., Echave, Julian, Wilke, Claus O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854464/
https://www.ncbi.nlm.nih.gov/pubmed/27138088
http://dx.doi.org/10.1371/journal.pbio.1002452