Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells

Inhibition of mammalian target of rapamycin-complex 1 (mTORC1) induces activation of Akt. Because Akt activity mediates the repair of ionizing radiation-induced DNA double-strand breaks (DNA-DSBs) and consequently the radioresistance of solid tumors, we investigated whether dual targeting of mTORC1...

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Detalles Bibliográficos
Autores principales: Holler, Marina, Grottke, Astrid, Mueck, Katharina, Manes, Julia, Jücker, Manfred, Rodemann, H. Peter, Toulany, Mahmoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854483/
https://www.ncbi.nlm.nih.gov/pubmed/27137757
http://dx.doi.org/10.1371/journal.pone.0154745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854483/
https://www.ncbi.nlm.nih.gov/pubmed/27137757
http://dx.doi.org/10.1371/journal.pone.0154745

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