GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130

WAC and GOLGA2/GM130 are 2 Golgi proteins that affect autophagy; however, their mechanism of action was unknown. We have shown that WAC binding to GOLGA2 at the Golgi displaces GABARAP from GOLGA2 to allow the maintenance of a nonlipidated centrosomal GABARAP pool. Centrosomal GABARAP can traffic to...

Descripción completa

Detalles Bibliográficos
Autores principales: Joachim, Justin, Tooze, Sharon A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Autophagic Puncta
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854544/
https://www.ncbi.nlm.nih.gov/pubmed/26986052
http://dx.doi.org/10.1080/15548627.2016.1159368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854544/
https://www.ncbi.nlm.nih.gov/pubmed/26986052
http://dx.doi.org/10.1080/15548627.2016.1159368

Ejemplares similares