GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130

WAC and GOLGA2/GM130 are 2 Golgi proteins that affect autophagy; however, their mechanism of action was unknown. We have shown that WAC binding to GOLGA2 at the Golgi displaces GABARAP from GOLGA2 to allow the maintenance of a nonlipidated centrosomal GABARAP pool. Centrosomal GABARAP can traffic to...

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Detalles Bibliográficos
Autores principales: Joachim, Justin, Tooze, Sharon A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Autophagic Puncta
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854544/
https://www.ncbi.nlm.nih.gov/pubmed/26986052
http://dx.doi.org/10.1080/15548627.2016.1159368
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author Joachim, Justin
Tooze, Sharon A.
author_facet Joachim, Justin
Tooze, Sharon A.
author_sort Joachim, Justin
collection PubMed
description WAC and GOLGA2/GM130 are 2 Golgi proteins that affect autophagy; however, their mechanism of action was unknown. We have shown that WAC binding to GOLGA2 at the Golgi displaces GABARAP from GOLGA2 to allow the maintenance of a nonlipidated centrosomal GABARAP pool. Centrosomal GABARAP can traffic to autophagic structures during starvation. In addition GABARAP specifically promotes ULK1 activation and this is independent of GABARAP lipidation but likely requires a LIR-mediated GABARAP-ULK1 interaction.
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spelling pubmed-48545442016-05-16 GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130 Joachim, Justin Tooze, Sharon A. Autophagy Autophagic Puncta WAC and GOLGA2/GM130 are 2 Golgi proteins that affect autophagy; however, their mechanism of action was unknown. We have shown that WAC binding to GOLGA2 at the Golgi displaces GABARAP from GOLGA2 to allow the maintenance of a nonlipidated centrosomal GABARAP pool. Centrosomal GABARAP can traffic to autophagic structures during starvation. In addition GABARAP specifically promotes ULK1 activation and this is independent of GABARAP lipidation but likely requires a LIR-mediated GABARAP-ULK1 interaction. Taylor & Francis 2016-03-17 /pmc/articles/PMC4854544/ /pubmed/26986052 http://dx.doi.org/10.1080/15548627.2016.1159368 Text en © 2016 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Autophagic Puncta
Joachim, Justin
Tooze, Sharon A.
GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130
title GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130
title_full GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130
title_fullStr GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130
title_full_unstemmed GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130
title_short GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130
title_sort gabarap activates ulk1 and traffics from the centrosome dependent on golgi partners wac and golga2/gm130
topic Autophagic Puncta
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854544/
https://www.ncbi.nlm.nih.gov/pubmed/26986052
http://dx.doi.org/10.1080/15548627.2016.1159368
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