The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

The integrated stress response (ISR) is a homeostatic mechanism by which eukaryotic cells sense and respond to stress-inducing signals, such as amino acid starvation. General controlled nonrepressed (GCN2) kinase is a key orchestrator of the ISR, and modulates cellular metabolism in response to amin...

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Detalles Bibliográficos
Autores principales: Ravindran, Rajesh, Loebbermann, Jens, Nakaya, Helder I, Khan, Nooruddin, Ma, Hualing, Gama, Leonardo, Machiah, Deepa K, Lawson, Benton, Hakimpour, Paul, Wang, Yi-chong, Li, Shuzhao, Sharma, Prachi, Kaufman, Randal J, Martinez, Jennifer, Pulendran, Bali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854628/
https://www.ncbi.nlm.nih.gov/pubmed/26982722
http://dx.doi.org/10.1038/nature17186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854628/
https://www.ncbi.nlm.nih.gov/pubmed/26982722
http://dx.doi.org/10.1038/nature17186

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