Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells

Many autoreactive B cells persist in the periphery in a state of unresponsiveness called anergy. This unresponsiveness is rapidly reversible, requiring continuous BCR interaction with self-antigen and resultant regulatory signaling for its maintenance. Using adoptive transfer of anergic B cells with...

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Detalles Bibliográficos
Autores principales: Getahun, Andrew, Beavers, Nicole A., Larson, Sandy R., Shlomchik, Mark J., Cambier, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854724/
https://www.ncbi.nlm.nih.gov/pubmed/27114609
http://dx.doi.org/10.1084/jem.20150537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854724/
https://www.ncbi.nlm.nih.gov/pubmed/27114609
http://dx.doi.org/10.1084/jem.20150537

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