Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

Autoantibodies against nucleic acids and excessive type I interferon (IFN) are hallmarks of human systemic lupus erythematosus (SLE). We previously reported that SLE neutrophils exposed to TLR7 agonist autoantibodies release interferogenic DNA, which we now demonstrate to be of mitochondrial origin....

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Detalles Bibliográficos
Autores principales: Caielli, Simone, Athale, Shruti, Domic, Bojana, Murat, Elise, Chandra, Manjari, Banchereau, Romain, Baisch, Jeanine, Phelps, Kate, Clayton, Sandra, Gong, Mei, Wright, Tracey, Punaro, Marilynn, Palucka, Karolina, Guiducci, Cristiana, Banchereau, Jacques, Pascual, Virginia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854735/
https://www.ncbi.nlm.nih.gov/pubmed/27091841
http://dx.doi.org/10.1084/jem.20151876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854735/
https://www.ncbi.nlm.nih.gov/pubmed/27091841
http://dx.doi.org/10.1084/jem.20151876

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