Automated synthesis of [(18)F]DCFPyL via direct radiofluorination and validation in preclinical prostate cancer models

BACKGROUND: Prostate-specific membrane antigen (PSMA) is frequently overexpressed and upregulated in prostate cancer. To date, various (18)F- and (68)Ga-labeled urea-based radiotracers for PET imaging of PSMA have been developed and entered clinical trials. Here, we describe an automated synthesis o...

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Detalles Bibliográficos
Autores principales: Bouvet, Vincent, Wuest, Melinda, Jans, Hans-Soenke, Janzen, Nancy, Genady, Afaf R., Valliant, John F., Benard, Francois, Wuest, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854855/
https://www.ncbi.nlm.nih.gov/pubmed/27142881
http://dx.doi.org/10.1186/s13550-016-0195-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854855/
https://www.ncbi.nlm.nih.gov/pubmed/27142881
http://dx.doi.org/10.1186/s13550-016-0195-6

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