Long‐lived hypopituitary Ames dwarf mice are resistant to the detrimental effects of high‐fat diet on metabolic function and energy expenditure

Growth hormone (GH) signaling stimulates the production of IGF‐1; however, increased GH signaling may induce insulin resistance and can reduce life expectancy in both mice and humans. Interestingly, disruption of GH signaling by reducing plasma GH levels significantly improves health span and extend...

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Detalles Bibliográficos
Autores principales: Hill, Cristal M., Fang, Yimin, Miquet, Johanna G., Sun, Liou Y., Masternak, Michal M., Bartke, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854906/
https://www.ncbi.nlm.nih.gov/pubmed/26990883
http://dx.doi.org/10.1111/acel.12467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854906/
https://www.ncbi.nlm.nih.gov/pubmed/26990883
http://dx.doi.org/10.1111/acel.12467

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