Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells

Recent high‐profile studies report GDF11 to be a key circulating ‘anti‐aging’ factor. However, a screen of extracellular proteins attempting to identify factors with ‘anti‐aging’ phenotypes in aged murine skeletal muscle satellite cells did not identify GDF11 activity. We have been unable to confirm...

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Detalles Bibliográficos
Autores principales: Hinken, Aaron C., Powers, Janine M., Luo, Guizhen, Holt, Jason A., Billin, Andrew N., Russell, Alan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Short Takes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854912/
https://www.ncbi.nlm.nih.gov/pubmed/27139744
http://dx.doi.org/10.1111/acel.12475
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author Hinken, Aaron C.
Powers, Janine M.
Luo, Guizhen
Holt, Jason A.
Billin, Andrew N.
Russell, Alan J.
author_facet Hinken, Aaron C.
Powers, Janine M.
Luo, Guizhen
Holt, Jason A.
Billin, Andrew N.
Russell, Alan J.
author_sort Hinken, Aaron C.
collection PubMed
description Recent high‐profile studies report GDF11 to be a key circulating ‘anti‐aging’ factor. However, a screen of extracellular proteins attempting to identify factors with ‘anti‐aging’ phenotypes in aged murine skeletal muscle satellite cells did not identify GDF11 activity. We have been unable to confirm the reported activity of GDF11, similar to other laboratories offering conflicting data and describe our attempts to do so in this short take.
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spelling pubmed-48549122016-06-16 Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells Hinken, Aaron C. Powers, Janine M. Luo, Guizhen Holt, Jason A. Billin, Andrew N. Russell, Alan J. Aging Cell Short Takes Recent high‐profile studies report GDF11 to be a key circulating ‘anti‐aging’ factor. However, a screen of extracellular proteins attempting to identify factors with ‘anti‐aging’ phenotypes in aged murine skeletal muscle satellite cells did not identify GDF11 activity. We have been unable to confirm the reported activity of GDF11, similar to other laboratories offering conflicting data and describe our attempts to do so in this short take. John Wiley and Sons Inc. 2016-03-28 2016-06 /pmc/articles/PMC4854912/ /pubmed/27139744 http://dx.doi.org/10.1111/acel.12475 Text en © 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Takes
Hinken, Aaron C.
Powers, Janine M.
Luo, Guizhen
Holt, Jason A.
Billin, Andrew N.
Russell, Alan J.
Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells
title Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells
title_full Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells
title_fullStr Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells
title_full_unstemmed Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells
title_short Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells
title_sort lack of evidence for gdf11 as a rejuvenator of aged skeletal muscle satellite cells
topic Short Takes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854912/
https://www.ncbi.nlm.nih.gov/pubmed/27139744
http://dx.doi.org/10.1111/acel.12475
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