Acetylation reduces SOX9 nuclear entry and ACAN gene transactivation in human chondrocytes

Changes in the content of aggrecan, an essential proteoglycan of articular cartilage, have been implicated in the pathophysiology of osteoarthritis (OA), a prevalent age‐related, degenerative joint disease. Here, we examined the effect of SOX9 acetylation on ACAN transactivation in the context of os...

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Detalles Bibliográficos
Autores principales: Bar Oz, Michal, Kumar, Ashok, Elayyan, Jinan, Reich, Eli, Binyamin, Milana, Kandel, Leonid, Liebergall, Meir, Steinmeyer, Juergen, Lefebvre, Veronique, Dvir‐Ginzberg, Mona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854920/
https://www.ncbi.nlm.nih.gov/pubmed/26910618
http://dx.doi.org/10.1111/acel.12456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854920/
https://www.ncbi.nlm.nih.gov/pubmed/26910618
http://dx.doi.org/10.1111/acel.12456

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