O‐GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease

Alzheimer's disease (AD) is characterized clinically by memory loss and cognitive decline. Protein kinase A (PKA)‐CREB signaling plays a critical role in learning and memory. It is known that glucose uptake and O‐GlcNAcylation are reduced in AD brain. In this study, we found that PKA catalytic...

Descripción completa

Detalles Bibliográficos
Autores principales: Xie, Shutao, Jin, Nana, Gu, Jianlan, Shi, Jianhua, Sun, Jianming, Chu, Dandan, Zhang, Liang, Dai, Chun‐ling, Gu, Jin‐hua, Gong, Cheng‐Xin, Iqbal, Khalid, Liu, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854926/
https://www.ncbi.nlm.nih.gov/pubmed/26840030
http://dx.doi.org/10.1111/acel.12449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854926/
https://www.ncbi.nlm.nih.gov/pubmed/26840030
http://dx.doi.org/10.1111/acel.12449

Ejemplares similares