Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response

Recent studies have proposed that the major anti-tumor effect of DNA methylation inhibitors is induction of interferon-responsive genes via dsRNAs-containing endogenous retroviruses. Recently, a 3D culture system for stem cells known as organoid culture has been developed. Lgr5-positive stem cells f...

Descripción completa

Detalles Bibliográficos
Autores principales: Saito, Yoshimasa, Nakaoka, Toshiaki, Sakai, Kasumi, Muramatsu, Toshihide, Toshimitsu, Kohta, Kimura, Masaki, Kanai, Takanori, Sato, Toshiro, Saito, Hidetsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855203/
https://www.ncbi.nlm.nih.gov/pubmed/27143627
http://dx.doi.org/10.1038/srep25311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855203/
https://www.ncbi.nlm.nih.gov/pubmed/27143627
http://dx.doi.org/10.1038/srep25311

Ejemplares similares