Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the Kynurenine Pathway in the mouse hippocampus

BACKGROUND: Increased tryptophan metabolism towards the production of kynurenine via indoleamine/tryptophan-2,3-dioxygenases (DOs: Ido1, Ido2, and Tdo2) is strongly associated with the prevalence of major depressive disorder in patients and the induction of depression-like behaviors in animal models...

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Detalles Bibliográficos
Autores principales: Brooks, Alexandra K., Lawson, Marcus A., Smith, Robin A., Janda, Tiffany M., Kelley, Keith W., McCusker, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855471/
https://www.ncbi.nlm.nih.gov/pubmed/27142940
http://dx.doi.org/10.1186/s12974-016-0563-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855471/
https://www.ncbi.nlm.nih.gov/pubmed/27142940
http://dx.doi.org/10.1186/s12974-016-0563-1

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