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Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the Kynurenine Pathway in the mouse hippocampus

BACKGROUND: Increased tryptophan metabolism towards the production of kynurenine via indoleamine/tryptophan-2,3-dioxygenases (DOs: Ido1, Ido2, and Tdo2) is strongly associated with the prevalence of major depressive disorder in patients and the induction of depression-like behaviors in animal models...

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Detalles Bibliográficos
Autores principales:	Brooks, Alexandra K., Lawson, Marcus A., Smith, Robin A., Janda, Tiffany M., Kelley, Keith W., McCusker, Robert H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855471/ https://www.ncbi.nlm.nih.gov/pubmed/27142940 http://dx.doi.org/10.1186/s12974-016-0563-1

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