Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood. Here we describe a role for asparagine as an amino acid exchange factor: intracellular asparagine exchanges with extracellular am...

Descripción completa

Detalles Bibliográficos
Autores principales: Krall, Abigail S., Xu, Shili, Graeber, Thomas G., Braas, Daniel, Christofk, Heather R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855534/
https://www.ncbi.nlm.nih.gov/pubmed/27126896
http://dx.doi.org/10.1038/ncomms11457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855534/
https://www.ncbi.nlm.nih.gov/pubmed/27126896
http://dx.doi.org/10.1038/ncomms11457

Ejemplares similares