The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[a]pyrene in human livers

Benzo[a]pyrene (BaP) is a human carcinogen that covalently binds to DNA after metabolic activation by cytochrome P450 (CYP) enzymes. In this study human recombinant CYPs (CYP1A1, 1A2, 1B1, 2A6, 2B6, 2C8, 2C9, 2C19, 2E1, 3A4, and 3A5) were expressed in Supersomes™ together with their reductases, NADP...

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Detalles Bibliográficos
Autores principales: Šulc, Miroslav, Indra, Radek, Moserová, Michaela, Schmeiser, Heinz H., Frei, Eva, Arlt, Volker M., Stiborová, Marie, White, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855618/
https://www.ncbi.nlm.nih.gov/pubmed/26919089
http://dx.doi.org/10.1002/em.22001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855618/
https://www.ncbi.nlm.nih.gov/pubmed/26919089
http://dx.doi.org/10.1002/em.22001

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