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Structure‐activity relationship of the peptide binding‐motif mediating the BRCA2:RAD51 protein–protein interaction
RAD51 is a recombinase involved in the homologous recombination of double‐strand breaks in DNA. RAD51 forms oligomers by binding to another molecule of RAD51 via an ‘FxxA’ motif, and the same recognition sequence is similarly utilised to bind BRCA2. We have tabulated the effects of mutation of this...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855620/ https://www.ncbi.nlm.nih.gov/pubmed/26992456 http://dx.doi.org/10.1002/1873-3468.12139 |