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Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy
Inactivation of p53 found in more than half of human cancers is often associated with increased tumor resistance to anti-cancer therapy. We have previously shown that overexpression of the phosphatase Wip1 in p53-negative tumors sensitizes them to chemotherapeutic agents, while protecting normal tis...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855675/ https://www.ncbi.nlm.nih.gov/pubmed/27077811 http://dx.doi.org/10.1038/cddis.2016.96 |