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TAK1 regulates Paneth cell integrity partly through blocking necroptosis

Paneth cells reside at the base of crypts of the small intestine and secrete antimicrobial factors to control gut microbiota. Paneth cell loss is observed in the chronically inflamed intestine, which is often associated with increased reactive oxygen species (ROS). However, the relationship between...

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Detalles Bibliográficos
Autores principales: Simmons, A N, Kajino-Sakamoto, R, Ninomiya-Tsuji, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855677/
https://www.ncbi.nlm.nih.gov/pubmed/27077812
http://dx.doi.org/10.1038/cddis.2016.98