UV-A Irradiation Activates Nrf2-Regulated Antioxidant Defense and Induces p53/Caspase3-Dependent Apoptosis in Corneal Endothelial Cells

PURPOSE: To examine whether Nrf2-regulated antioxidant defense and p53 are activated in human corneal endothelial cells (CEnCs) by environmental levels of ultraviolet A (UV-A), a known stimulator of oxidative stress. METHODS: Immortalized human CEnCs (HCEnCi) were exposed to UV-A fluences of 2.5, 5,...

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Detalles Bibliográficos
Autores principales: Liu, Cailing, Vojnovic, Dijana, Kochevar, Irene E., Jurkunas, Ula V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2016
Materias:
Cornea
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855825/
https://www.ncbi.nlm.nih.gov/pubmed/27127932
http://dx.doi.org/10.1167/iovs.16-19097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855825/
https://www.ncbi.nlm.nih.gov/pubmed/27127932
http://dx.doi.org/10.1167/iovs.16-19097

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