Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection

The detection of somatic mutations from cancer genome sequences is key to understanding the genetic basis of disease progression, patient survival and response to therapy. Benchmarking is needed for tool assessment and improvement but is complicated by a lack of gold standards, by extensive resource...

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Detalles Bibliográficos
Autores principales: Ewing, Adam D, Houlahan, Kathleen E, Hu, Yin, Ellrott, Kyle, Caloian, Cristian, Yamaguchi, Takafumi N, Bare, J Christopher, P’ng, Christine, Waggott, Daryl, Sabelnykova, Veronica Y, Kellen, Michael R, Norman, Thea C, Haussler, David, Friend, Stephen H, Stolovitzky, Gustavo, Margolin, Adam A, Stuart, Joshua M, Boutros, Paul C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856034/
https://www.ncbi.nlm.nih.gov/pubmed/25984700
http://dx.doi.org/10.1038/nmeth.3407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856034/
https://www.ncbi.nlm.nih.gov/pubmed/25984700
http://dx.doi.org/10.1038/nmeth.3407

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