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The effects of anthocyanin-rich wheat diet on the oxidative status and behavior of rats

AIM: To evaluate the effect of food containing anthocyanin-rich wheat on oxidative status and behavior of healthy rats. METHODS: Twenty male rats were divided into the control and anthocyanin group. Oral glucose tolerance test was performed, and proteinuria and creatinine clearance were measured. Be...

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Autores principales: Janšáková, Katarína, Bábíčková, Janka, Havrlentová, Michaela, Hodosy, Július, Kraic, Ján, Celec, Peter, Tóthová, Ľubomíra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Medical Schools 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856190/
https://www.ncbi.nlm.nih.gov/pubmed/27106354
http://dx.doi.org/10.3325/cmj.2016.57.119
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author Janšáková, Katarína
Bábíčková, Janka
Havrlentová, Michaela
Hodosy, Július
Kraic, Ján
Celec, Peter
Tóthová, Ľubomíra
author_facet Janšáková, Katarína
Bábíčková, Janka
Havrlentová, Michaela
Hodosy, Július
Kraic, Ján
Celec, Peter
Tóthová, Ľubomíra
author_sort Janšáková, Katarína
collection PubMed
description AIM: To evaluate the effect of food containing anthocyanin-rich wheat on oxidative status and behavior of healthy rats. METHODS: Twenty male rats were divided into the control and anthocyanin group. Oral glucose tolerance test was performed, and proteinuria and creatinine clearance were measured. Behavioral analysis was performed in Phenotyper cages. Serum and tissues were collected to measure the markers of oxidative stress and antioxidant status. RESULTS: Anthocyanins significantly increased total antioxidant capacity in serum (P = 0.039), decreased advanced oxidation protein products in the kidney (P = 0.002), but increased thiobarbituric acid reactive substances in the kidney compared to the control group. No significant difference between the groups was found in the markers of oxidative stress in the liver and colon, as well as in renal functions and glucose metabolism. The anthocyanin group spent significantly less time in the spotlight zone of the Phenotyper cages (P = 0.040), indicating higher anxiety-like behavior. CONCLUSION: Food containing anthocyanin-rich wheat had positive effects on serum antioxidant status and kidney protein oxidation, but increased lipid peroxidation in the kidney and modified animal behavior related to anxiety. The molecular mechanisms leading to observed effects should be further elucidated.
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spelling pubmed-48561902016-05-20 The effects of anthocyanin-rich wheat diet on the oxidative status and behavior of rats Janšáková, Katarína Bábíčková, Janka Havrlentová, Michaela Hodosy, Július Kraic, Ján Celec, Peter Tóthová, Ľubomíra Croat Med J RECOOP for Common Mechanisms of Disease AIM: To evaluate the effect of food containing anthocyanin-rich wheat on oxidative status and behavior of healthy rats. METHODS: Twenty male rats were divided into the control and anthocyanin group. Oral glucose tolerance test was performed, and proteinuria and creatinine clearance were measured. Behavioral analysis was performed in Phenotyper cages. Serum and tissues were collected to measure the markers of oxidative stress and antioxidant status. RESULTS: Anthocyanins significantly increased total antioxidant capacity in serum (P = 0.039), decreased advanced oxidation protein products in the kidney (P = 0.002), but increased thiobarbituric acid reactive substances in the kidney compared to the control group. No significant difference between the groups was found in the markers of oxidative stress in the liver and colon, as well as in renal functions and glucose metabolism. The anthocyanin group spent significantly less time in the spotlight zone of the Phenotyper cages (P = 0.040), indicating higher anxiety-like behavior. CONCLUSION: Food containing anthocyanin-rich wheat had positive effects on serum antioxidant status and kidney protein oxidation, but increased lipid peroxidation in the kidney and modified animal behavior related to anxiety. The molecular mechanisms leading to observed effects should be further elucidated. Croatian Medical Schools 2016-04 /pmc/articles/PMC4856190/ /pubmed/27106354 http://dx.doi.org/10.3325/cmj.2016.57.119 Text en Copyright © 2016 by the Croatian Medical Journal. All rights reserved. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle RECOOP for Common Mechanisms of Disease
Janšáková, Katarína
Bábíčková, Janka
Havrlentová, Michaela
Hodosy, Július
Kraic, Ján
Celec, Peter
Tóthová, Ľubomíra
The effects of anthocyanin-rich wheat diet on the oxidative status and behavior of rats
title The effects of anthocyanin-rich wheat diet on the oxidative status and behavior of rats
title_full The effects of anthocyanin-rich wheat diet on the oxidative status and behavior of rats
title_fullStr The effects of anthocyanin-rich wheat diet on the oxidative status and behavior of rats
title_full_unstemmed The effects of anthocyanin-rich wheat diet on the oxidative status and behavior of rats
title_short The effects of anthocyanin-rich wheat diet on the oxidative status and behavior of rats
title_sort effects of anthocyanin-rich wheat diet on the oxidative status and behavior of rats
topic RECOOP for Common Mechanisms of Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856190/
https://www.ncbi.nlm.nih.gov/pubmed/27106354
http://dx.doi.org/10.3325/cmj.2016.57.119
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