NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap(4)A) and Down-Regulates Immune Response and Cancer Promotion Genes

Regulation of gene expression is one of several roles proposed for the stress-induced nucleotide diadenosine tetraphosphate (Ap(4)A). We have examined this directly by a comparative RNA-Seq analysis of KBM-7 chronic myelogenous leukemia cells and KBM-7 cells in which the NUDT2 Ap(4)A hydrolase gene...

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Detalles Bibliográficos
Autores principales: Marriott, Andrew S., Vasieva, Olga, Fang, Yongxiang, Copeland, Nikki A., McLennan, Alexander G., Jones, Nigel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856261/
https://www.ncbi.nlm.nih.gov/pubmed/27144453
http://dx.doi.org/10.1371/journal.pone.0154674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856261/
https://www.ncbi.nlm.nih.gov/pubmed/27144453
http://dx.doi.org/10.1371/journal.pone.0154674

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