Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

T17M rhodopsin expression in rod photoreceptors leads to severe retinal degeneration and is associated with the activation of ER stress related Unfolded Protein Response (UPR) signaling. Here, we show a novel role of a UPR transcription factor, ATF4, in photoreceptor cellular pathology. We demonstra...

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Detalles Bibliográficos
Autores principales: Bhootada, Yogesh, Kotla, Pravallika, Zolotukhin, Sergei, Gorbatyuk, Oleg, Bebok, Zsuzsanna, Athar, Mohammad, Gorbatyuk, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856272/
https://www.ncbi.nlm.nih.gov/pubmed/27144303
http://dx.doi.org/10.1371/journal.pone.0154779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856272/
https://www.ncbi.nlm.nih.gov/pubmed/27144303
http://dx.doi.org/10.1371/journal.pone.0154779

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